Oxygen Saturation and Outcomes in Preterm Infants

Oxygen Saturation and Outcomes in Preterm Infants

Publisher: 
New England Journal of Medicine
Date published: 
2013
Record type: 
Corporate Author: 
The BOOST II United Kingdom
Journal Title: 
The New England Journal of Medicine
Source: 
The New England Journal of Medicine, Vol. 368, No. 22, May 30, 2013, pp. 2094-2104
Abstract: 

The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. A total of 2448 infants were recruited. Among the 1187 infants whose treatment used the revised oximeter-calibration algorithm, the rate of death was significantly higher in the lower-target group than in the higher-target group (23.1% vs. 15.9%; relative risk in the lower-target group, 1.45; 95% confidence interval [CI], 1.15 to 1.84; P=0.002). There was heterogeneity for mortality between the original algorithm and the revised algorithm (P=0.006) but not for other outcomes. In all 2448 infants, those in the lower-target group for oxygen saturation had a reduced rate of retinopathy of prematurity (10.6% vs. 13.5%; relative risk, 0.79; 95% CI, 0.63 to 1.00; P=0.045) and an increased rate of necrotizing enterocolitis (10.4% vs. 8.0%; relative risk, 1.31; 95% CI, 1.02 to 1.68; P=0.04). There were no significant between-group differences in rates of other outcomes or adverse events.

Language: 

CITATION: The BOOST II United Kingdom. Oxygen Saturation and Outcomes in Preterm Infants . : New England Journal of Medicine , 2013. The New England Journal of Medicine, Vol. 368, No. 22, May 30, 2013, pp. 2094-2104 - Available at: https://library.au.int/oxygen-saturation-and-outcomes-preterm-infants-4