Prone Positioning in Severe Acute Respiratory Distress Syndrome

Prone Positioning in Severe Acute Respiratory Distress Syndrome

Author: 
Guerin, Claude [etal]
Publisher: 
New England Journal of Medicine
Date published: 
2013
Record type: 
Journal Title: 
The New England Journal of Medicine
Source: 
The New England Journal of Medicine, Vol. 368, No. 23, June 6, 2013, pp. 2159-2168
Abstract: 

Previous trials involving patients with the acute respiratory distress syndrome (ARDS) have failed to show a beneficial effect of prone positioning during mechanical ventilatory support on outcomes. We evaluated the effect of early application of prone positioning on outcomes in patients with severe ARDS. A total of 237 patients were assigned to the prone group, and 229 patients were assigned to the supine group. The 28-day mortality was 16.0% in the prone group and 32.8% in the supine group (P<0.001). The hazard ratio for death with prone positioning was 0.39 (95% confidence interval [CI], 0.25 to 0.63). Unadjusted 90-day mortality was 23.6% in the prone group versus 41.0% in the supine group (P<0.001), with a hazard ratio of 0.44 (95% CI, 0.29 to 0.67). The incidence of complications did not differ significantly between the groups, except for the incidence of cardiac arrests, which was higher in the supine group.

Language: 

CITATION: Guerin, Claude [etal]. Prone Positioning in Severe Acute Respiratory Distress Syndrome . : New England Journal of Medicine , 2013. The New England Journal of Medicine, Vol. 368, No. 23, June 6, 2013, pp. 2159-2168 - Available at: https://library.au.int/prone-positioning-severe-acute-respiratory-distress-syndrome-4